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Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice

✍ Scribed by Shuei Sugama; Lichuan Yang; Byung Pil Cho; Lorraine A DeGiorgio; Stefan Lorenzl; David S Albers; M.Flint Beal; Bruce T Volpe; Tong H Joh


Book ID
113999010
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
988 KB
Volume
964
Category
Article
ISSN
0006-8993

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✍ Hélène Turmel; Andreas Hartmann; Karine Parain; Aicha Douhou; Anu Srinivasan; Yv 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB

## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP