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Age-related defects in the cytoskeleton signaling pathways of CD4 T cells

✍ Scribed by Gonzalo G. Garcia; Richard A. Miller


Book ID
116255303
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
310 KB
Volume
10
Category
Article
ISSN
1872-9649

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Age-related defects in CD4+ T cell activ
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CD4(+) T cells from old mice show defects in the activation process including deficiency in the formation of immunosynapses with antigen-presenting cells. We show that CD4(+) T cells from old mice express unusually high levels of glycosylated forms of the bulky T cell glycoprotein CD43, particularly