✦ LIBER ✦

Age-related changes in ovarian responsiveness to gonadotropins in normal and neonatally estrogenized mice

✍ Scribed by Mori, Takao

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 598 KB
Volume: 207
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402070313

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Young ovariectomized mice were transplanted with ovaries obtained from either neonatally estrogenized or normal mice at different ages. Cyclic estrus ensued in 71% of the mice receiving ovarian grafts from 3‐month‐old normal donors. If donors were 12, 15 and 20 months old, cyclic estrus took place in 15, 10 and 0% of the recipients, respectively. By contrast, after transplantation of ovaries from neonatally estrogenized mice, aged 3, 12 or 15 months, cyclic estrus occurred in about 42–48% of the recipients regardless of the age of donors. Three of 17 recipients receiving ovarian grafts from 20‐month‐old neonatally estrogenized donors still showed cyclic estrus. Therefore, in neonatally estrogenized mice, decline of ovarian responsiveness to circulating gonadotropins appears to be inhibited or delayed until at least 15 months of age.

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