Age- and tumor-correlated changes in functional antibody responses to MTV in neonatally infected mice

✍ Scribed by Phyllis B. Blair; Mary-Ann Lane

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: French
• Weight: 695 KB
• Volume: 25
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910250216

✦ Synopsis

Abstract

BALB/cfC3H female mice (neonatally infected with MTV) possess several different specific antibody activities measured functionally by reactivity with MTV‐associated antigens expressed on the surface of isologous MTV‐induced mammary tumor target cells. All females when young develop serum antibody which can block specific T‐cell cytotoxic activity of BALB/cfC3H spleen cells; this activity remains detectable throughout life. In addition, recruiting antibody is found in the postweaning stage. This recruiting activity is apparently directed against the same antigenicity as the blocking activity; it can be detected only rarely in whole serum but is revealed in the 19S fraction when the competing blocking antibodies are sequestered into the 7S fraction. In mid‐adult life, 19S recruiting activity is found in only a few of the females; the incidence increases as the females age, and it occurs earlier in those females which subsequently develop mammary tumors. A third antibody activity of serum is blocking factor directed against different MTV‐associated tumor‐cell‐surface antigenicity; this blocks the antibody‐dependent cell‐mediated cytotoxicity characteristic of spleen cells from BALB/c females horizontally exposed to MTV‐associated antigenicity. This blocking activity of serum is not found in young females, and in the older females it is more frequent in those which develop mammary tumors.