## ABSTRACT The mdx mouse has been used as an animal model for human Duchenne muscular dystrophy (DMD). Unlike DMD, skeletal muscles of mdx mice undergo successful regeneration and do not show extensive fibrosis and functional impairment. Growth factors have been proposed to be involved in muscle g
Age-related calmitine distribution in mitochondria of normal and mdx mouse skeletal muscle
✍ Scribed by Brigitte Lucas-Héron; Nelly Schmitt; Béatrice Ollivier
- Book ID
- 118931019
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 324 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-510X
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## Abstract The distribution of fibronectin in normal and regenerating skeletal muscle (the latter caused by autotransplantation) was investigated by means of indirect immunofluorescent technique. Normal myofibers exhibited a thin, continuous pericellular (endomysium) fibronectin distribution; howe
Duchenne muscular dystrophy is an X-linked devastating disease due to the lack of expression of a functional dystrophin. Unfortunately, the dystrophin-deficient mdx mouse model does not present clinical signs of dystrophy before the age of 18 months, and the role of dystrophin in fiber integrity is