We analyzed the data on age at onset and CAG size of 319 patients clinically diagnosed with Huntington disease (HD) and 86 presymptomatic subjects recorded by four Italian Centers over the last 14 years. To overcome the problem of different CAG numbers found in each subject, also in the same family,
β¦ LIBER β¦
Age of onset, age at examination, and other covariates in the analysis of family data
β Scribed by Dr. R. C. Elston; V. T. George
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 173 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
β¦ Synopsis
Information on age of onset can easily be incorporated into regressive logistic models by assuming that age of onset follows a logistic distribution. This is analogous to previously proposed models based on the normal distribution. The two distributions, and hence the two types of models, are very similar. In each case the generalized modulus power transformation can be used as a basis for more flexibly modeling the age of onset distribution.
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