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Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation

✍ Scribed by Hitoshi Takahashi; Daiki Okamura; Marlene E. Starr; Hiroshi Saito; B. Mark Evers


Book ID
115281789
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
618 KB
Volume
11
Category
Article
ISSN
1474-9718

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Suppression of the PI3K subunit p85α del
✍ Susan M.R. Gurney; Peter Forster; Ursula Just; Ralf Schwanbeck 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

Phosphatidylinositol-3-kinases (PI3Ks) exert a variety of signaling functions in eukaryotes. We suppressed the PI3K regulatory subunit p85a using a small interfering RNA (Pik3r1 siRNA) and examined the effects on embryoid body (EB) development in hanging drop culture. We observed a 150% increase in