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The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

✍ Scribed by Park, Sang Won; Zhou, Yingjiang; Lee, Justin; Lu, Allen; Sun, Cheng; Chung, Jason; Ueki, Kohjiro; Ozcan, Umut


Book ID
109926260
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
788 KB
Volume
16
Category
Article
ISSN
1078-8956

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Suppression of the PI3K subunit p85α del
✍ Susan M.R. Gurney; Peter Forster; Ursula Just; Ralf Schwanbeck 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

Phosphatidylinositol-3-kinases (PI3Ks) exert a variety of signaling functions in eukaryotes. We suppressed the PI3K regulatory subunit p85a using a small interfering RNA (Pik3r1 siRNA) and examined the effects on embryoid body (EB) development in hanging drop culture. We observed a 150% increase in