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AEG-1 Is a Target of Perifosine and Is Over-Expressed in Gastric Dysplasia and Cancers

✍ Scribed by Huang, Wenbin; Yang, Li; Liang, Song; Liu, Dongxiao; Chen, Xi; Ma, Zhuo; Zhai, Sulan; Li, Ping; Wang, Xuerong

Book ID: 125358590
Publisher: Springer US
Year: 2013
Tongue: English
Weight: 527 KB
Volume: 58
Category: Article
ISSN: 0163-2116
DOI: 10.1007/s10620-013-2735-5

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## Abstract The NADPH‐oxidase 1 (Nox1) is a homolog of gp91__phox__, the catalytic subunit of the phagocyte superoxide‐generating NADPH‐oxidase. Nox1 is expressed in normal colon epithelial cells and in colon tumor cell lines, and overexpression in model cells has been implicated in stimulation of