CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer
โ Scribed by Liu, Qiang; Teh, Ming; Ito, Kosei; Shah, Nilesh; Ito, Yoshiaki; Yeoh, Khay Guan
- Book ID
- 109889650
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 1022 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0893-3952
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Loss of heterozygosity (LOH) or decreased expression of the deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene, has been suggested to correlate with progression in several types of tumors. In human gastric cancers, although DCC LOH has been reported to be frequent in expandin
CDX2 is a tumor-suppressor homeobox gene involved in colon carcinogenesis, but its role in gastric cancer is unknown. Although GATA4, -5 and, -6 transcription factors have distinct functions in the regulation of gastrointestinal epithelial cell differentiation, there have been no reports regarding G