๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Advances in tenascin-C biology

โœ Scribed by Kim S. Midwood; Thomas Hussenet; Benoit Langlois; Gertraud Orend

Book ID
105759568
Publisher
Springer
Year
2011
Tongue
English
Weight
593 KB
Volume
68
Category
Article
ISSN
1420-682X

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โœฆ Synopsis

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

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A recent study by Mitrovic and Schachner (J Neurosci Res 42:710-717, 1995) reported the detection of a small amount of truncated tenascin-C (TN-C) in the nervous system of the TN-C knockout mice created by Saga et al. (Genes Dev 6:1821-1831, 1992). The authors suggested that the truncated protein mi

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We have investigated the expression of tenascin-C (TN-C) in the somatosensory cortex of early postnatal mutant mice in which lac2 was reported to be expressed in place of tenascin (Saga et al.: Genes Dev 6:1821-1831, 1992). At both the mRNA and protein levels, TN-C was detected at levels lower in th