Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment
β Scribed by Matthew A. Picchietti; Daniel L. Picchietti
- Book ID
- 116884833
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 351 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1389-9457
No coin nor oath required. For personal study only.
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The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more lasting relief also occurs for iron treatment in some patients. Thus there are two major putative causes for RLS: CNS dopaminerg
## Abstract Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging f