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Multiregional brain iron deficiency in restless legs syndrome

✍ Scribed by Jana Godau; Uwe Klose; Adriana Di Santo; Katherine Schweitzer; Daniela Berg

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 119 KB
Volume: 23
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22070

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9–7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = −0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. © 2008 Movement Disorder Society

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