Advanced glycosylation end products stimulate collagen mRNA synthesis in mesangial cells mediated by protein kinase C and transforming growth factor–beta

Matrix protein synthesis by glomerular m

Matrix protein synthesis by glomerular mesangial cells in culture: Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA

✍ Gertrud Maria Hänsch; Christof Wagner; Antje Bürger; Wenjie Dong; G. Staehler; M 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 732 KB

The pathogenesis of glornerular scarring i s multifactional; recent evidence suggests that transforming growth factor P (TGFP), a pleiotropic cicatricial mediator, may promote mesangial sclerosis by enhancing the production of extracellular matrix proteins. We studied the effect of TGFPl and TFGP2 o