Adult bone and mineral working group abstracts WG16–WG35

• Publisher: American Society for Bone and Mineral Research
• Year: 2003
• Tongue: English
• Weight: 319 KB
• Volume: 18
• Category: Article
• ISSN: 0884-0431
• DOI: 10.1002/jbmr.5650181309

✦ Synopsis

Hypovitaminosis-D and osteoporosis is common in subjects with rheumatoid arthritis (RA) residing in temperate climate. No information is available in Indian subcontinent, region with abundant sunshine. We studied calcium metabolism, calcium intake, sun exposure, serum 25(OH)D3 and bone mineral density (DXA) at lumbar spine (L1-4-AP) and hip region in 95 women with RA (age 48.0 "b10.4yrs, disease duration 9.1 "b6.5yrs). Dietary calcium intake and average sun exposure were 914"b513 mg/day and 16.3"b12 min/day respectively. Hypocalcemia (S.Ca<8.5mg/dl), hypophosphatemia (S.iP<3mg/dl), elevated s. alkaline phosphatase (>150 IU/L) were present in 18%, 15%, and 46% respectively. Vitamin-D deficiency (S.25(OH)D3 <15ng/ml) and severe vitamin-D deficiency (<8ng/ml) was present in 44% and 18% respectively. Osteoporosis (T score <2.5) was observed at LS-AP (39%), total hip (25%), femoral neck (40%). Glucocorticoids treated women had lower T-score (p>0.05) and Z-score (p<0.05) at all sites. Calcium supplemented group (50%) had higher serum 25(OH)D3 levels (p<0.03) but had similar BMD as compared to non-supplemented group. BMD at LS and total hip had negative correlation (p<0.05) with age, disease duration, age of onset but not with glucocorticoids, S.25(OH)D levels and sun-exposure. This study emphasizes high prevalence of hypovitaminosis-D and osteoporosis in women with RA from Indian subcontinent, thereby needing preventive measures.