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Adsorption of fibrinogen on modified polytetrafluoroethylene surfaces

✍ Scribed by Ziegler, T. F. ;Miller, M. L.

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
514 KB
Volume
4
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

The adsorption of radiotagged fibrinogen on modified polytetrafluoroethylene surfaces was measured to shed light on the reason of reduced thrombogenicity. These measurements show that when fibrinogen is adsorbed from a solution in which the molecules are in a coiled, undenatured state, adsorption is greater on sulfonated, etched Teflon—a reduced thrombogenic surface, than on unsulfonated, etched Teflon—a thrombogenic surface. On the other hand, when fibrinogen is picked up from a water‐air interface in the form of a monolayer consisting of denatured molecules, the pick‐up is independent of the thrombogenicity of the surface.

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