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Adsorption of Amyloid Beta (1-40) Peptide to Phosphatidylethanolamine Monolayers

✍ Scribed by Elena Maltseva; Gerald Brezesinski


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
196 KB
Volume
5
Category
Article
ISSN
1439-4235

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Elevated levels of zinc 2+ and copper 2+ are found chelated to the amyloid-beta-peptide (Ah) in isolated senile plaque cores of Alzheimer's disease (AD) patients. However, the precise residues involved in Zn 2+ ligation are yet to be established. We have used 1 H NMR and CD to probe the binding of Z