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Adsorption and Penetration of Hepatitis B Virus in a Nonpermissive Cell Line

✍ Scribed by Ming Qiao; Thomas B. Macnaughton; Eric J. Gowans

Book ID
112269776
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
550 KB
Volume
201
Category
Article
ISSN
0042-6822

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The human hepatoblastoma-derived cell line HB6 I I secretes hepatitis-B surface antigen (HBsAg) and hepatitis-B e antigen (HBeAg) into the medium. Hepatitis-B-virus(HBV) DNA integrated into the cellular genome was found to be hypermethylated. When the cells were treated with 5-azacytidine for 3 days