Homozygous inactivation of the LGI1 gene
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Jeane Silva; Suash Sharma; Bernard Hughes; Y. Eugene Yu; John K. Cowell
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Article
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2010
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John Wiley and Sons
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English
β 474 KB
## Abstract Mutations in the __LGI1__ gene in humans predispose to the development of autosomal dominant partial epilepsy with auditory features (ADPEAF). Homozygous inactivation of the __Lgi1__ gene in mice results in an epilepsy phenotype characterized by clonic seizures within 2β3 weeks after bi