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Adolescent obsessive compulsive disorder heralding chorea-acanthocytosis

✍ Scribed by Mark Walterfang; Murat Yucel; Ruth Walker; Andrew Evans; Benedikt Bader; Ashley Ng; Adrian Danek; Ramon Mocellin; Dennis Velakoulis

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
70 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We describe one male and one female patient who each developed childhood/adolescent obsessive‐compulsive disorder as a prelude to the development of a typical picture of chorea‐acanthocytosis (ChAc). In each patient, the caudate nucleus showed dramatic atrophy. The role of the caudate in compulsive phenomena, and the predilection for neurological disorders with onset in adolescence to present as major mental illness, is discussed. On the basis of the current evidence and previous findings, we suggest that ChAc can be understood as a disorder whose clinical presentation reflects an interaction between the disease process and the individual's neurodevelopmental stage with both initial interrupted neurodevelopment, and supervening neurodegeneration. © 2007 Movement Disorder Society

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