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Paraneoplastic chorea with leukoencephalopathy presenting with obsessive–compulsive and behavioral disorder

✍ Scribed by Susanne Muehlschlegel; Michael S. Okun; Kelly D. Foote; Dominique Coco; Anthony T. Yachnis; Hubert H. Fernandez

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
230 KB
Volume
20
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Chorea is a rare manifestation of paraneoplastic disease and is associated with CV2/CRMP‐5 antibodies. Obsessive–compulsive disorder and large‐scale white matter abnormalities on MRI have not been previously reported in association with these antibodies. We report on a case of CV2 paraneoplastic syndrome with obsessive–compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI. The literature on paraneoplastic chorea is reviewed. © 2005 Movement Disorder Society

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