𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Adjuvant polyarthritis. vii. The role of type ii collagen in pathogenesis

✍ Scribed by Yoshio Iizuka; Yi-Han Chang

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
768 KB
Volume
25
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The development of immune response in rats directed toward EL4 cells, after the injection of EL4 cells suspended in a saline/oil emulsion, was enhanced by the incorporation of Mycobacterium into the saline/oil emulsion; the incorporation of type II collagen into the saline–acetic acid/oil emulsion in concentrations ranging from 0.5–25 μg/ml had no apparent effect on the development of immune response. The incorporation of type II collagen into the saline–acetic acid/oil emulsion at higher concentrations (100 μg and 1.0 mg/ml) significantly suppressed both the humoral and the cell‐mediated immune response. Pretreatment of rats with the maximal subarthritogenic dose of complete Freund's adjuvant prevented the development of arthritis in response to a subsequent injection of an arthritogenic dose of the same adjuvant, but had no effect on the development of type II collagen–induced arthritis. These observations suggest that adjuvant arthritis and the type II collagen–induced arthritis are distinctly different diseases.

📜 SIMILAR VOLUMES

Pathogenesis of osteoarthritis-like chan
Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagen
✍ K. Hu; L. Xu; L. Cao; C. M. Flahiff; J. Brussiau; K. Ho; L. A. Setton; I. Youn; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 647 KB

## Abstract ## Objective To examine the pathogenetic mechanisms of osteoarthritis (OA)–like changes in Col9a1^−/−^ mice, which are deficient in type IX collagen. ## Methods Knee joints and temporomandibular joints (TMJs) from Col9a1^−/−^ mice and their wild‐type (Col9a1^+/+^) littermates were ex

The role of type I collagen in the regul
The role of type I collagen in the regulation of the osteoblast phenotype
✍ Songtao Shi; Martin Kirk; Arnold J. Kahn 📂 Article 📅 2009 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 716 KB

Evidence from a variety of sources indicates that the extracellular matrix forms an important part of a feedback loop governing the migration, proliferation, and differentiation of the cells that produce it. In keeping with this, we showed previously that the extracellular matrix of a multipotential