𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Adjusting for Covariates in Variance Components QTL Linkage Analysis

✍ Scribed by Maurice Zeegers; Fruhling Rijsdijk; Pak Sham

Book ID
111572960
Publisher
Springer US
Year
2004
Tongue
English
Weight
102 KB
Volume
34
Category
Article
ISSN
0001-8244

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Estimating the power of variance compone
Estimating the power of variance component linkage analysis in large pedigrees
✍ Wei-Min Chen; GonΓ§alo R. Abecasis πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 202 KB πŸ‘ 1 views

## Abstract Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped individual than small pedigrees. We propose accurate and computat

Variance-components methods for linkage
Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees
✍ G. Diao; D. Y. Lin πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 110 KB πŸ‘ 1 views

## Abstract Many complex human diseases such as alcoholism and cancer are rated on ordinal scales. Well‐developed statistical methods for the genetic mapping of quantitative traits may not be appropriate for ordinal traits. We propose a class of variance‐component models for the joint linkage and a

Gamma regression improves Haseman-Elston
Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs
✍ Mathew J. Barber; Heather J. Cordell; Alex J. MacGregor; Toby Andrew πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 163 KB

## Abstract Existing standard methods of linkage analysis for quantitative phenotypes rest on the assumptions of either ordinary least squares (Haseman and Elston [1972] Behav. Genet. 2:3–19; Sham and Purcell [2001] Am. J. Hum. Genet. 68:1527–1532) or phenotypic normality (Almasy and Blangero [1998