Adhesion to Bone Marrow Stroma Inhibits Apoptosis of Chronic Lymphocytic Leukemia Cells
✍ Scribed by Lagneaux, Laurence; Delforge, Alain; de Bruyn, Cécile; Bernier, Michel; Bron, Dominique
- Book ID
- 121488324
- Publisher
- Informa plc
- Year
- 1999
- Tongue
- English
- Weight
- 800 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1042-8194
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📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND Patients with chronic lymphocytic leukemia (CLL) that transforms to Richter syndrome (RS) frequently show atypical lymphocytes in bone marrow; however, a diagnosis of RS requires confirmation of the presence of sheets of large cells in bone marrow or lymph nodes. ## METH
Using a sensitive immunohistochemical technique and a specific monoclonal antibody (RFD-3), follicular dendritic cells (FDC) have been demonstrated in a significant proportion (6/12) of bone marrow samples from patients with nodular marrow involvement of B-cell chronic lymphocytic leukemia (B-CLL).