Adherence of extracellular matrix components to modified surfaces of titanium alloys

✍ Scribed by C. Stelzer; E. Uhlmann; M. Meinke; J. Lademann; U. Hansen

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 630 KB
• Volume: 6
• Category: Article
• ISSN: 1612-2011
• DOI: 10.1002/lapl.200810131

✦ Synopsis

The adherence of biological materials on metal surfaces is of special importance in biology and medicine. The underlying interactions between surface and biological materials (e.g. extracellular matrix components or cells) are responsible for the application as a medical device. Numerous products are made of pure titanium and titanium alloys. This paper shows the influence of a laser production technology on machined surfaces of TiAl 6 V 4 and the resulting adherence of biological material on the basis of the surface characterisation. In this study, different machined TiAl 6 V 4 surfaces were used for coatings with extracellular matrix components. For this process, different coating with collagen I monomers and a complex mixture of extracellular matrix proteins derived from the dermalepidermal basement membrane zone were analysed. The efficiency of the coating was analysed by different methods and the results are presented in this paper. 5 μm 5 μm (a) (b) SEM picture of a laser machined surface (feed rate = 400 mm/s (a) and 500 mm/s (b); zoom: 20000×), inhomogeneous surfaces