Adenovirus-Mediated Gene Transfer to the Central Nervous System for Parkinson's Disease
✍ Scribed by Philippe Horellou; Olivier Sabaté; Marie-Hélène Buc-Caron; Jacques Mallet
- Book ID
- 117979453
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 87 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0014-4886
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Various regions of the brain have been successfully transduced by recombinant adeno-associated virus (rAAV) vectors with no detected toxicity. When using the cytomegalovirus immediate early (CMV) promoter, a gradual decline in the number of transduced cells has been described. In contrast, the use o
Background Canavan disease (CD) is an autosomal recessive leukodystrophy characterized by de®ciency of aspartoacylase (ASPA) and increased levels of N-acetylaspartic acid (NAA) in brain and body ¯uids, severe mental retardation and early death. Gene therapy has been attempted in a number of children