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Adenovirus-mediated gene transfer of adiponectin reduces osteoclasts differentiation and bone erosion of collagen-induced arthritis in mice

✍ Scribed by K. Ebina⁎; K. Oshima; M. Hirao; J. Hashimoto; T. Ochi; H. Yoshikawa; I. Shimomura


Book ID
116322983
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
102 KB
Volume
47
Category
Article
ISSN
8756-3282

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## Abstract ## Objective The phosphatidylinositol 3‐kinase (PI 3‐kinase)/Akt pathway is known to be activated in rheumatoid arthritis (RA) synovial tissue, which impacts cell growth, proliferation, survival, and migration. Phosphatase and tensin homolog deleted from chromosome 10 (PTEN) functions