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Adenovirus-mediated gene transfer of adiponectin reduces osteoclasts differentiation and bone erosion of collagen-induced arthritis in mice

✍ Scribed by K. Ebina; K. Oshima; A. Fukuhara; M. Hirao; A. Nampei; J. Hashimoto; H. Yoshikawa; I. Shimomura


Book ID
116321621
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
99 KB
Volume
44
Category
Article
ISSN
8756-3282

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## Abstract ## Objective The phosphatidylinositol 3‐kinase (PI 3‐kinase)/Akt pathway is known to be activated in rheumatoid arthritis (RA) synovial tissue, which impacts cell growth, proliferation, survival, and migration. Phosphatase and tensin homolog deleted from chromosome 10 (PTEN) functions