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Adenovirus Infection Inactivates the Translational Inhibitors 4E-BP1 and 4E-BP2

✍ Scribed by Anne-Claude Gingras; Nahum Sonenberg

Book ID
118771280
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
346 KB
Volume
237
Category
Article
ISSN
0042-6822

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Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1
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## Abstract To clarify the higher eukaryotic initiation factor 4E (eIF4E) binding selectivity of 4E‐binding protein 2 (4E‐BP2) than of 4E‐BP1, as determined by Trp fluorescence analysis, the crystal structure of the eIF4E binding region of 4E‐BP2 in complex with m^7^GTP‐bound human eIF4E has been d