Adenosine receptors in the cardiovascular system

✍ Scribed by Ray A. Olsson

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 774 KB
• Volume: 39
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199611/12)39:3/4<301::aid-ddr9>3.0.co;2-v

✦ Synopsis

The remarkably comprehensive qualitative description of the cardiovascular actions of adenosine by Drury and Szent-Gyorgyi [(1920): J Physiol 6:213-2371 serves as a framework for current research on the cellular and molecular mechanisms of those actions. This article reviews eight areas in this field that have advanced significantly during the past 5 years: (1) the kinds of potassium channels coupled to the cardiomyocyte A1 AR; (2) the mechanism of the "anti-adrenergic" action of adenosine; (3) the role of adenosine in angina pectoris; (4) the role of adenosine in ischemic preconditioning; (5) the occurrence of AzAR in ventricular myocytes; (6) evidence for A,-, A**-, A 2 ~-and A3ARs in blood vessels; (7) the role of nitric oxide in adenosine-initiated vasodilation; and ( ) the effect of adenosine on microvascular permeability. In some areas, solid evidence has defined a particular mechanism; in others, the evidence is as yet incomplete.