Adenosine receptors involved in the bronchoconstrictor effect of adenosine

✍ Scribed by Guy F. Joos; Romain A. Pauwels

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 312 KB
• Volume: 39
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199611/12)39:3/4<330::aid-ddr13>3.0.co;2-5

✦ Synopsis

Adenosine may play a role in the airflow obstruction in asthma and chronic obstructive pulmonary disease. Although the mechanism of adenosine-induced bronchoconstriction has been well explored, little is known about the identity of adenosine-receptors involved. Studies on rabbit and rat airways suggest that multiple receptors (Al, A ~B , and A3 receptors) may be involved in the bronchoconstrictor of adenosine. Mast cell mediators contribute to adenosine-induced bronchoconstriction. Studies on isolated mast cell lines have revealed the presence of A26 and A3 receptors. The in vitro contraction of human bronchi is mediated by an adenosine receptor (A, or Az?). A2 receptors have been demonstrated by ligand binding in human peripheral airways. The presence of the A3 receptor has been shown by in situ hybridization in eosinophils and mesenchymal tissue. The development of potent and specific adenosine receptor agonists and antagonists will increase our knowledge on this issue and may offer new therapeutic approaches to obstructive airway diseases. Drug Dev. Res. 39:330-332, 1996.