Adenosine inhibits glutamate stimulated [3H]d-aspartate release from cerebellar granule cells
β Scribed by DREJER, J; FRANDSEN, A; HONORE, T; SCHOUSBOE, A
- Book ID
- 122400668
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 411 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0197-0186
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π SIMILAR VOLUMES
Neurotransmitter release in response to either 55 mM K + or 25 pM glutamate as well as its dependency on Ca2' from different sources was compared in cultured glutamatergic cerebellar granule cells from rat brain. The intracellular Ca2+ concentration was monitored at the single cell level in neurites
The effect of nicotine on basal and electrically evoked (20 Hz for 20 sec) [(3)H]D-aspartate efflux (assumed as an index of transmitter release) was studied in rat cerebellar granule primary cultures. Nicotine (10-100 nM) increased the basal efflux two to three times and concentration-dependently en