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Adenosine A2A receptor antagonism potentiates l-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats

✍ Scribed by Sandro Fenu; Annalisa Pinna; Ennio Ongini; Micaela Morelli


Book ID
119413641
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
188 KB
Volume
321
Category
Article
ISSN
0014-2999

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In rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, striatal D,-receptor-stimulated c-fos expression and turning behavior are positively modulated by D, receptor stimulation and by blockade of N-methyl-D-aspartate (NMDA) or muscarinic receptors. Combined D1