Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia
β Scribed by Senda, Takao (author);Iizuka-Kogo, Akiko (author);Onouchi, Takanori (author);Shimomura, Atsushi (author)
- Book ID
- 106238980
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 567 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0918-4287
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Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm