Adeno-associated virus vectors
โ Scribed by Barrie J. Carter
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 779 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
โฆ Synopsis
Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome integration may be site specific and occur at preferred sites in the human genome. Several genes relevant to the treatment of genetic or infectious diseases have been expressed in adeno-associated virus vectors in vitro.
๐ SIMILAR VOLUMES
## Abstract ## Background Several genes are candidates for treating inner ear diseases. For clinical applications, minimally invasive approaches to the inner ear are desirable along with minimal sideโeffects. ## Methods Adenoโassociated virus (AAV) was used as a vector into the guinea pig inner
## Abstract Vectors derived from adenoโassociated virus type 2 (AAV2) are promising gene delivery vehicles, but it is still challenging to get the large number of recombinant adenoโassociated virus (rAAV) particles required for large animal and clinical studies. Current transfection technology requ
## Abstract ## Background Gene transfer offers considerable potential for altering vessel wall physiology and intervention in vascular disease. Therefore, there is great interest in developing optimal strategies and vectors for efficient, targeted gene delivery into a vessel wall. ## Methods We