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Adeno-associated virus expression systems for gene transfer

✍ Scribed by Joseph E Rabinowitz; Jude Samulski

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
552 KB
Volume
9
Category
Article
ISSN
0958-1669

No coin nor oath required. For personal study only.

✦ Synopsis

In contrast to other gene delivery systems, adeno-associated virus vectors show long term gene expression without immune response or toxicity. New production methods have increased vector titers and eliminated adenovirus contamination, thereby facilitating effective in vivo use. These advancements will expedite additional animal model studies providing validation for use of this vector in human clinical trials.

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