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Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice

✍ Scribed by Masafumi Yoshino; Yoshimichi Nakatsu; Hein te Riele; Seiichi Hirota; Yukihiko Kitamura; Kiyoji Tanaka


Book ID
117798878
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
121 KB
Volume
1
Category
Article
ISSN
1568-7864

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Ultraviolet light B (UVB)-induced mutagenesis was studied in gpt delta transgenic mice, which contain the EG10 shuttle vector as a transgene. The mice were exposed to UVB at single doses of 0.3, 0.5, 1.0, 1.5, and 2.0 kJ/m 2 . At 4 weeks after irradiation, the mutant frequencies (MF) of the gpt gene