The enantioselective hydrogenations of ethyl pyruvate (EP), methyl benzoylformate (MBF), ketopantolactone (KPL) and pyruvaldehyde dimethylacetal (PADA) were studied on Pt-alumina catalyst modified by a new modifier namely ␣-isoquinine (␣-IQ) with rigid conformation and for comparison by quinine (Q)
Additional data to the origin of rate enhancement in the enantioselective hydrogenation of activated ketones over cinchonidine modified platinum catalyst
✍ Scribed by Emília Tálas; József L. Margitfalvi; Orsolya Egyed
- Book ID
- 113686675
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 378 KB
- Volume
- 266
- Category
- Article
- ISSN
- 0021-9517
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## Abstract The enantioselective hydrogenation of methoxy‐ and fluorine‐substituted (__E__)‐2,3‐diphenylpropenoic acid derivatives was studied over cinchonidine‐modified, supported palladium catalysts in the absence and presence of benzylamine as additive. The fluorine substituent in the appropriat
The origin of rate enhancement in the enantioselective heterogeneous catalytic hydrogenation of ethyl pyruvate on Pt modified with the parent cinchonas, as compared to the unmodified Pt, was studied in a solvent mixture toluene/AcOH 9/1. Hydrogenation experiments were carried out in a continuousflow