Addition of α-Halo-Substituted Carbonitriles to Aldehydes and Ketones in the Presence of Iron Pentacarbonyl.
✍ Scribed by T. T. Vasil'eva; N. A. Kuz'mina; O. V. Chakhovskaya; N. E. Mysova; A. B. Terent'ev
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 29 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Reformatsky-Type Addition of Esters of α-Halogeno Carboxylic Acids to Aldehydes and Ketones in the Presence of Fe(CO) 5 . -Fe(CO) 5 -promoted Reformatsky-type addition of α-halogenocarboxylates to carbonyl compounds affords the corresponding β-hydroxycarboxylates (III) (12 examples) in moderate to
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## Abstract Efficient addition of functionalized organozinc reagents to various carbonyl derivatives and CO~2~ is achieved in the presence of MgCl~2~.