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Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts: Total Synthesis of (+)-Cannabisativine

โœ Scribed by Kuethe, Jeffrey T.; Comins, Daniel L.


Book ID
127362438
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
61 KB
Volume
2
Category
Article
ISSN
1523-7060

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Regioselective addition of titanium enol
โœ Daniel L. Comins; Jack D. Brown ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 180 KB

Titanium enolates add to the 4-position of l-phenoxycarbonylpyridinium salts to give 1,4\_dihydropyridines; subsequent aromatization provides 4-(2-oxoalkyl)pyridines. Development of practical methods for directing nucleophiles to the 4-position of a pyridine ring has been a challenge to synthetic ch