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Adaptive regulation of hepatic bile salt transport: Effects of alloxan diabetes in the rat

✍ Scribed by Miguel A. Icarte; Margarita Pizarro; Luigi Accatino

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 917 KB
Volume: 14
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840140416

No coin nor oath required. For personal study only.

✦ Synopsis

of bile flow. Insulin treatment (3 units/100 g m body wt/day) in diabetic rats from day 0 (alloxan injection) to day 14 (INS-14 group) and from day 14 to day 24 after alloxan administration (INS-24 group) normalized basal bile salt secretion, taurocholate maximum secretory rate and the bile salt-independent fraction of bile flow. Bile salt pool size was significantly greater in DIAB-14 and DIAB-24 groups than in the control group (172% and 216% greater, respectively) and the PHARM-control group (246% and 309% greater, respectively). Insulin treatment prevented, in the INS-14 group, and reversed, in the INS-24 group, the increase of bile salt pool. Cholestyramine administration (5% wt/wt in the diet) to diabetic rats from day 0 (alloxan injection) to day 14 (CHOL-14 group) and from day 14 to day 24 after alloxan administration (CHOL-24 group) prevented and reversed, respectively, bile salt pool and taurocholate maximum secretory rate increase without modifying the hyperglycemia.

In conclusion, alloxan diabetes brings about marked changes in taurocholate maximum secretory rate, that appear to be selective, because sulfobromophthalein maximum secretory rate is unaltered. Both enhanced and decreased taurocholate maximum secretory rate appear to be primarily related to, and follow, parallel changes in bile salt (cholate) pool size induced by diabetes. Both insulin and cholestyramine can prevent and reverse the enhancement of taurocholate maximum secretory rate induced by diabetes. Thus changes in taurocholate maximum secretory rate in this experimental model probably represent an adaptive response to increased hepatic bile salt load, supporting the concept that bile salt pool size is an important factor in the down-regulation and upregulation of hepatic bile salt transport.

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