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Adaptive Evolution of UGT2B17 Copy-Number Variation

✍ Scribed by Yali Xue; Donglin Sun; Allan Daly; Fengtang Yang; Xue Zhou; Mengyao Zhao; Ni Huang; Tatiana Zerjal; Charles Lee; Nigel P. Carter; Matthew E. Hurles; Chris Tyler-Smith

Book ID
113422521
Publisher
American Society of Human Genetics
Year
2008
Tongue
English
Weight
854 KB
Volume
83
Category
Article
ISSN
0002-9297

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Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism
✍ Vincent MΓ©nard; Olivier Eap; Mario Harvey; Chantal Guillemette; Γ‰ric LΓ©vesque πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 531 KB

UGT2B17 and UGT2B28 are among the most commonly deleted genes in humans and encode members of the uridine diphosphate (UDP)-glucuronosyltransferase 2B (UGT2B) subfamily. They are involved, along with UGT2B15, in the catabolism of sex-steroid hormones. Despite the recent biomedical interest in UGT2B1