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Genome-wide Copy-Number-Variation Study Identified a Susceptibility Gene, UGT2B17, for Osteoporosis

✍ Scribed by Tie-Lin Yang; Xiang-Ding Chen; Yan Guo; Shu-Feng Lei; Jin-Tang Wang; Qi Zhou; Feng Pan; Yuan Chen; Zhi-Xin Zhang; Shan-Shan Dong; Xiang-Hong Xu; Han Yan; Xiaogang Liu; Chuan Qiu; Xue-Zhen Zhu; Teng Chen; Meng Li; Hong Zhang; Liang Zhang; Betty M. Drees; James J. Hamilton; Christopher J. Papasian; Robert R. Recker; Xiao-Ping Song; Jing Cheng; Hong-Wen Deng

Book ID
113422553
Publisher
American Society of Human Genetics
Year
2008
Tongue
English
Weight
806 KB
Volume
83
Category
Article
ISSN
0002-9297

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✍ Vincent MΓ©nard; Olivier Eap; Mario Harvey; Chantal Guillemette; Γ‰ric LΓ©vesque πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 531 KB

UGT2B17 and UGT2B28 are among the most commonly deleted genes in humans and encode members of the uridine diphosphate (UDP)-glucuronosyltransferase 2B (UGT2B) subfamily. They are involved, along with UGT2B15, in the catabolism of sex-steroid hormones. Despite the recent biomedical interest in UGT2B1