Adaptive Design Methods in Clinical Trials, Second Edition

✍ Scribed by Chang, Mark; Chow, Shein-Chung

Publisher: Not Avail;CRC Press
Year: 2012
Tongue: English
Leaves: 368
Series: Chapman & Hall/CRC biostatistics series
Edition: 2nd ed
Category: Library

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✦ Synopsis

Adaptive Design Methods in Clinical Trials, Second Edition

✦ Table of Contents

Content: Protocol amendment --
Adaptive randomization --
Adaptive hypotheses --
Adaptive dose-escalation trials --
Adaptive group sequential design --
Statistical tests for adaptive seamless designs --
Adaptive sample size adjustment --
Two-stage adaptive design --
Adaptive treatment switching --
Bayesian approach --
Biomarker adaptive trials --
Target clinical trials --
Sample size and power estimation --
Clinical trial simulation --
Regulatory perspectives : a review of FDA draft guidance.

✦ Subjects

Clinical trials;Adaptive sampling (Statistics);Experimental design;Clinical trials -- Statistical methods;MEDICAL -- Laboratory Medicine;Clinical Trials -- methods;Research Design;Biometry -- methods;Models, Statistical

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