Adaptive Design Methods in Clinical Trials

✍ Scribed by Shein-Chung Chow (Author); Mark Chang (Author)

Publisher: Chapman and Hall/CRC
Year: 2011
Leaves: 368
Edition: 2
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA`s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini

✦ Table of Contents

Introduction. Protocol Amendment. Adaptive Randomization. Adaptive Hypotheses. Adaptive Dose-Escalation Trials. Adaptive Group Sequential Design. Statistical Tests for Seamless Adaptive Designs. Adaptive Sample Size Adjustment. Two-Stage Adaptive Design. Adaptive Treatment Switching. Bayesian Approach. Biomarker Adaptive Trials. Target Clinical Trials. Sample Size and Power Estimation. Clinical Trial Simulation. Regulatory Perspectives- A Review of FDA Draft Guidance. Case Studies. Bibliography. Subject Index.

✦ Subjects

Bioscience;Pharmaceutical Science;Clinical Trials - Pharmaceutical Science;Medicine, Dentistry, Nursing & Allied Health;Medicine;Medical Statistics & Computing

📜 SIMILAR VOLUMES

Adaptive Design Methods in Clinical Tria

📁 Adaptive Design Methods in Clinical Trials (Biostatistics)

✍ Shein-Chung Chow, Mark Chang 📂 Library 📅 2006 🏛 Chapman and Hall/CRC 🌐 English

Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to a

Adaptive Design Methods in Clinical Tria

📁 Adaptive Design Methods in Clinical Trials, Second Edition

✍ Chang, Mark; Chow, Shein-Chung 📂 Library 📅 2012 🏛 Not Avail;CRC Press 🌐 English

Adaptive Design Methods in Clinical Trials, Second Edition

Clinical Trial Design: Bayesian and Freq

📁 Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

✍ Guosheng Yin(auth.) 📂 Library 📅 2012 🌐 English

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, fre

Randomised Response-Adaptive Designs in

📁 Randomised Response-Adaptive Designs in Clinical Trials

✍ Anthony C Atkinson, Atanu Biswas 📂 Library 📅 2013 🏛 Chapman and Hall/CRC 🌐 English

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statistici

Group Sequential and Confirmatory Adapti

📁 Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

✍ Gernot Wassmer, Werner Brannath (auth.) 📂 Library 📅 2016 🏛 Springer International Publishing 🌐 English

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under

Bayesian Methods and Ethics in a Clinica

📁 Bayesian Methods and Ethics in a Clinical Trial Design

📂 Library 📅 1996 🌐 English

How to conduct clinical trials in an ethical and scientifically responsible manner This book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case--involvi