Adaptive control of specific growth rate based on proton production in anaerobic fed-batch culture
β Scribed by J. I. Won; Y. L. Yang; B. G. Kim; C. Y. Choi
- Publisher
- Springer Netherlands
- Year
- 1993
- Tongue
- English
- Weight
- 258 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0141-5492
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β¦ Synopsis
This paper develops a practical and useful computer control scheme to control the specific growth rate as accurately as possible by measuring the released protons in anaerobic alcohol fermentation.
In the. case of current study, most of the released protons are due to the uptake of cationic ammonium ion via the conversion: NH4' * NHj(cel1) + H'. Correlating the Proton Production (PP) and the Proton Production Rate (PPR) with specitic growth rate (u) proved PP as a better measured variable. Using a simple adaptive control algorithm, cc was successfully controlled in a Zvmomonas mobilis fed-batch culture.
π SIMILAR VOLUMES
A computer-based algorithm was used for the open-loop control of specific growth rate in fedbatch cultures of recombinant E.coli.. The control of nutrient feed rate to an exponential trajectory resulted in growth of the culture at a constant specific growth rate. Stable specific growth rates between