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Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1

✍ Scribed by Jason Long; Tejas Manchandia; Kechen Ban; Shan Gao; Claudia Miller; Joya Chandra

Book ID
105992456
Publisher
Springer
Year
2006
Tongue
English
Weight
356 KB
Volume
59
Category
Article
ISSN
0344-5704

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## Abstract Extracellular acidosis (EA) regulates Heme Oxygenase‐1 (HO‐1) expression in vascular smooth muscle cells via transcriptional and posttranscriptional mechanisms but the signaling pathways involved are not known. We examined the role of Mitogen‐Activated Protein Kinase (MAPK) pathways in