Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the
ADAMTS proteases: key roles in atherosclerosis?
β Scribed by Rebecca C. Salter; Tim G. Ashlin; Alvin P. L. Kwan; Dipak P. Ramji
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 198 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0946-2716
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## Abstract Brain tumors, in particular glioblastomas, have a high morbidity and mortality, mainly due to their invasive nature. A prerequisite for this invasiveness is cell migration based on increased expression of proteases digesting the extracellular matrix. Brevican, an important extracellular