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ADAM17-Mediated Cleavage is Required for HPP1-Associated Tumor Suppression in Colorectal Cancer

✍ Scribed by W. Clark; A. Elahi; J. Wang; J. Hernandez; D. Shibata

Book ID
116708336
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
41 KB
Volume
172
Category
Article
ISSN
0022-4804

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## Abstract ## BACKGROUND Akt/protein kinase B (PKB), which is included in phosphatidyl inositol‐3‐OH kinase (PI3K) signaling, controls many intracellular processes, such as the suppression of apoptosis and the promotion of the cell cycle. Therefore, the authors investigated phosphorylated Akt (Se