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Acylguanidines as Small-Molecule β-Secretase Inhibitors

✍ Scribed by Cole, Derek C.; Manas, Eric S.; Stock, Joseph R.; Condon, Jeffrey S.; Jennings, Lee D.; Aulabaugh, Ann; Chopra, Rajiv; Cowling, Rebecca; Ellingboe, John W.; Fan, Kristi Y.; Harrison, Boyd L.; Hu, Yun; Jacobsen, Steve; Jin, Guixan; Lin, Laura; Lovering, Frank E.; Malamas, Michael S.; Stahl, Mark L.; Strand, James; Sukhdeo, Mohani N.; Svenson, Kristine; Turner, M. James; Wagner, Erik; Wu, Junjun; Zhou, Ping; Bard, Jonathan

Book ID
121267349
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
244 KB
Volume
49
Category
Article
ISSN
0022-2623

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Tryptoline, a core structure of ochrolifuanine E, which is a hit compound from virtual screening of the Thai herbal database against BACE1 was used as a scaffold for the design of BACE1 inhibitors. The tryptoline was linked with different side chains by 1,2,3-triazole ring readily synthesized by cat